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Grifths, Professor Gareth G.O.Grifths**[ta]**on.ac.uk

University of Southampton Clinical Trials Unit University of Southampton 01/10/2013 30/09/2018 Clinical and Translational Research Committee - Clinical Trials Unit - Programme Award Clinical Trials Awards & Advisory Committee

CRUK/07/003: T-SCOPE: Collection and storage of tissue and blood samples from patients with oesophageal cancer in the SCOPE 1 Clinical trial for future translational research Velindre NHS Trust 01/05/2007 30/09/2015 Clinical Trials Awards & Advisory Committee - Sample Collection Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Grifths, Dr Robert robert.grifths**[ta]**ted.ox.ac.uk

Quality and outcomes of care for chronic conditions in older patients diagnosed with breast, colorectal, or prostate cancer compared to non-cancer controls: An observational study using the clinical practice research datalink (CPRD) University of Oxford 01/07/2013 29/02/2016 Population Research Committee - Project Award Population Research Committee

Grundy, Professor Richard richard.grundy**[ta]**tingham.ac.uk

CRUK/12/036: SIOP Intracranial Ependymoma II; An international clinical trial for the diagnosis and treatment of children, adolescents and young adults with intracranial Ependymoma University of Birmingham 01/03/2015 28/02/2025 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Guettler, Dr Sebastian sebastian.guettler**[ta]**.ac.uk

A structure-function analysis of the poly(ADP-ribose) polymerase Tankyrase in cellular signalling Institute of Cancer Research 01/07/2013 30/06/2019 New Investigator Committee - Career Establishment Award New Investigator Committee

Hackshaw-McGeagh, Dr Lucy lucy.hackshaw**[ta]**stol.ac.uk

A Week In Your Life University of Bristol 01/11/2014 31/12/2015 Population Research Committee - BUPA Foundation Fund - Innovation Grant Population Research Committee

Hagan, Professor Iain Iain.Hagan**[ta]**k.manchester.ac.uk

Control of mitotic commitment and progression Cancer Research UK Manchester Institute 01/01/2013 31/12/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Hagemann, Professor Thorsten t.hagemann**[ta]**l.ac.uk

Mammalian target of rapamycin (mTOR) regulates innate immune function in the tumour microenvironment Queen Mary, University of London 01/12/2011 30/11/2017 New Investigator Committee - Senior Cancer Research Fellowship New Investigator Committee

Mammalian target of rapamycin (mTOR) regulates innate immune function in the tumour microenvironment Queen Mary, University of London 01/06/2012 31/05/2016 New Investigator Committee - Studentship New Investigator Committee

Hajek, Professor Peter p.hajek**[ta]**l.ac.uk

Can electronic cigarettes help disadvantaged smokers who struggle to quit? Queen Mary, University of London 01/09/2015 28/02/2017 Tobacco Advisory Group - Project Award Tobacco Advisory Group

Halbert, Professor Gavin g.w.halbert**[ta]**ath.ac.uk

Equipment grant for Cancer Research UK Formulation Unit.University of Strathclyde 01/04/2015 31/03/2016 New Agents Committee - Programme Award New Agents Committee

Hall, Dr Emma emma.hall**[ta]**.ac.uk

CRUKE/12/025: PACE - The PACE Trial (Prostate Advances in Comparative Evidence) International randomised study of laparoscopic prostatectomy vs stereotactic body radiotherapy (SBRT) and conventionally fractionated radiotherapy vs SBRT for early stage organ-confned prostate cancer Institute of Cancer Research 01/08/2012 31/07/2022 Clinical Trials Awards & Advisory Committee - Endorsement - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/12/021: A phase II trial of vinflunine in locallyadvanced and metastatic carcinoma of the penis (VinCaP) Institute of Cancer Research 01/06/2013 30/09/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.CRUK/07/004: BOXIT: A Randomised phase III placebo-controlled trial evaluating the addition of celecoxib to standard treatment of transitional cell carcinoma of the bladder Institute of Cancer Research 01/02/2007 31/01/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/06/016: CHHIP: a randomised phase III multicentre trial of conventional or hypofractionated high dose intensity modulated radiotherapy for prostate cancer Institute of Cancer Research 01/08/2006 31/07/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/08/004: COSTAR: A Multicentre Randomised Study Of Cochlear Sparing Intensity Modulated Radiotherapy Versus Conventional Radiotherapy in Patients with Parotid Tumours Institute of Cancer Research 01/09/2008 31/08/2016 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/09/011: 111 Testis: A single arm multi-centre study evaluating a single cycle of BEP as adjuvant chemotherapy in high risk, stage 1 non-seminomatous germ cell tumours of the testis (NSGCTT).Institute of Cancer Research 01/08/2009 31/01/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/10/018: ART-DECO: A randomised accelerated radiotherapy study of dose escalated IMRT vs conventional dose IMRT in patients receiving treatment for Laryngeal and Hypopharyngeal cancer.Institute of Cancer Research 01/09/2010 31/08/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/11/027: POUT: Peri-Operative chemotherapy or sUrveillance in upper Tract urothelial cancer Institute of Cancer Research 01/12/2011 30/11/2020 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/11/053: PROMPTS: A Prospective Randomised phase III study of Observation versus screening MRI and Pre-emptive Treatment in castrate resistant prostate cancer patients with Spinal metastasis.Institute of Cancer Research 01/10/2012 31/03/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/12/055: HYBRID - A multicentre randomised phase II study of HYpofractionated Bladder Radiotherapy with or without Image guided aDaptivepredictive planning Institute of Cancer Research 01/11/2013 31/10/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Hall, Dr Marcia marcia.hall**[ta]**.net CRUKE/11/024: METRO-BIBF Phase II, randomised, placebo controlled, multicentre, feasibility study of low dose (metronomic) cyclophosphamide with and without BIBF1120 in advanced ovarian cancer University College London 01/08/2014 31/07/2016 Clinical Trials Awards & Advisory Committee - Endorsement - Feasibility Study Clinical Trials Awards & Advisory CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Committee

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Halloran, Mr Christopher halloran**[ta]**.ac.uk

CRUKE/13/019: Cattell Warren versus Blumgart techniques of pancreatico-jejunostomy following pancreato-duodenectomy - a double blinded multicentred trial (PANasta) University of Liverpool 01/05/2014 30/04/2019 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Commit***

Hammond, Dr Ester ester.hammond**[ta]**ology.ox.ac.uk

Hypoxia Group University of Oxford 01/11/2013 31/10/2018 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Hardie, Professor D Grahame d.g.hardie**[ta]**dee.ac.uk

AMP-activated protein kinase - a tumour suppressor that opposes the metabolic changes in proliferating cells University of Dundee 01/01/2013 31/12/2017 Science Committee - Programme Award Science Committee

Hargrave, Dr Darren darren.hargrave**[ta]**.net CRUKD/09/044 A CR-UK/CCLG Phase I paediatric trial of AT9283, a selective aurora kinase inhibitor, in relapsed and refractory solid tumours Royal Marsden NHS Foundation Trust 01/01/2008 30/09/2017 New Agents Committee - DD Project Proposal New Agents Committee

Harrington, Professor Kevin kevin.harrington**[ta]**.ac.uk

Physical and biological optimisation of radiotherapy in head and neck cancer Institute of Cancer Research 01/04/2012 31/03/2017 Clinical and Translational Research Committee - Programme Award Science Committee

CRUK/13/016: A randomised phase II study to evaluate the efcacy and safety of chemotherapy vs androgen deprivation therapy in patients with recurrent and/ or metastatic, androgen receptor expressing, salivary gland cancer (EORTC-1206-HNCG) - an International Rare Cancers Initiative Study - IRCI 007 Institute of Cancer Research 01/03/2014 31/10/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUKD/14/007 PATRIOT: A Phase I trial to assess tolerability, safety and biological effects of AZD6738, a specifc Ataxia Telangiectasia and Rad3-related (ATR) inhibitor, as a single agent and in combination with palliative radiation therapy in patients with solid tumours Royal Marsden NHS Foundation Trust 01/05/2014 30/04/2016 New Agents Committee - Trial Grant Application New Agents Committee

Harris, Professor Adrian adrian.harris**[ta]**ology.ox.ac.uk

Preclinical development and CRUKD/07/061: A Cancer Research UK Phase I frst in human study to determine the MTD of oral Src/ABL inhibitor AZD0424, and to identify tolerable and effective AZD0424 combination regimens for the treatment of advanced solid tumours The Churchill Hospital 01/10/2007 31/07/2018 New Agents Committee - DD Project Proposal New Agents Committee

Exploratory & preclinical development & CRUKD/18/001 a frst in class frst in human Phase I study of huATN-658 humanised monoclonal antibody to uPAR scaffold with expansion to Phase Ib biomarker led trial University of Oxford 01/06/2014 31/08/2020 New Agents Committee - DD Project Proposal New Agents CommitteeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Role of notch signalling and hypoxia in resistance to anti-angiogenic therapy University of Oxford 01/10/2010 30/09/2015 Science Committee - Programme Award Science Committee

Hartley, Professor John john.hartley**[ta]**.ac.uk

Drug-induced DNA damage and its repair University College London 01/10/2013 30/09/2018 Science Committee - Programme Award Science Committee

Hartsuiker, Dr Edgar Analysis of MRN-dependent and -independent topoisomerase removal mechanisms: implications for resistance against Camptothecin and Etoposide derivatives Bangor University 01/09/2010 31/12/2015 Biological Sciences Committee - Career Establishment Award Science Committee

Hatton, Dr Matthew CRUK/14/040 ADSCaN - A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemoradiotherapy in Non Small Cell Lung Cancer NHS Greater Glasgow and Clyde 01/07/2015 28/02/2021 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Hawkins, Professor Maria maria.hawkins**[ta]**ology.ox.ac.uk

CRUK/14/029: Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers (ABC-07) University College London 01/01/2015 31/12/2017 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

CRUK/14/028: SPARC: A Phase I trial of pre-operative, margin intensive, stereotactic body radiation therapy for previously untreated borderline resectable pancreatic cancer University of Oxford 01/11/2014 28/02/2018 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

Hay, Professor Ronald r.t.hay**[ta]**dee.ac.uk

The Promyelocytic Leukaemia protein as a target in cancer therapy University of Dundee 01/12/2011 30/11/2016 Science Committee - Programme Award Science Committee

Hayday, Professor Adrian adrian.hayday**[ta]**.ac.uk

Immuno Surveillance Laboratory The Francis Crick Institute 01/06/2012 31/05/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive Board

Hayes, Professor John j.d.hayes**[ta]**dee.ac.uk

Molecular mechanisms by which the cancer chemopreventive properties of transcription factor Nrf2 are regulated through its Neh6 redox-independent phosphodegrons as a consequence of GSK3 activity University of Dundee 01/04/2012 30/09/2015 Biological Sciences Committee - Project Award Science Committee

Higgins, Dr Geoff geoffrey.higgins**[ta]**ology.ox.ac.uk

Investigation of the Molecular Basis of Tumour Radiosensitivity University of Oxford 01/01/2012 31/12/2015 Clinical Careers Committee - Clinician Scientist Fellowship Clinical Careers Committee

CRUKD/12/016: A CR-UK Phase I study of PI3K inhibitor BKM120 in patients with non-small cell lung cancer receiving thoracic radiotherapy University of Oxford 01/09/2012 31/08/2017 New Agents Committee - Trial Grant Application New Agents Committee

Hill, Dr Caroline caroline.hill**[ta]**ck.ac.uk

TGF-beta superfamily signalling in early vertebrate development and cancer The Francis Crick Institute 01/11/2012 31/10/2017 Scientifc Executive Board - Institute Group Award Scientifc Executive BoardCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Hillmen, Professor Peter p.hillmen**[ta]**ds.ac.uk

CRUK/12/037: NCRI CLL10 - Phase III trial to assess ibrutinib+R against FCR in newly diagnosed patients with Chronic Lymphocytic Leukaemia (CLL) University of Leeds 01/02/2013 30/04/2022 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Hills, Dr Robert CRUK/12/043: AML 18 - A trial for older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome Cardiff University 01/06/2013 31/05/2018 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/13/35: AML19 Trial - A trial for acute myeloid leukaemia and high risk myelodysplastic syndrome in younger patients Cardiff University 01/06/2014 31/05/2020 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Hiom, Professor Kevin k.hiom**[ta]**dee.ac.uk

Molecular function of BRCA1 in the maintenance of genome stability and breast cancer University of Dundee 01/11/2011 31/10/2016 Science Committee - Programme Award Science Committee

Hochegger, Dr Helfrid h.hochegger**[ta]**sex.ac.uk

Exploiting chemical genetics to investigate the control of microtubule dynamics by mitotic kinases University of Sussex 01/10/2012 30/09/2018 New Investigator Committee - Senior Cancer Research Fellowship New Investigator Committee

Exploiting chemical genetics to investigate the control of microtubule dynamics by mitotic kinases University of Sussex 01/10/2012 30/09/2016 New Investigator Committee - Studentship New Investigator Committee

Hochhauser, Professor Daniel CRUKD/12/015: PANtHER a Phase I/II study of EGFR inhibitor AZD8931 in combination with FOLFIRI to determine the importance of schedule and activity in colorectal cancer University College London 01/05/2013 30/06/2017 New Agents Committee - Trial Grant Application New Agents Committee

Hodivala-Dilke, Professor Kairbaan k.hodivala-dilke**[ta]**l.ac.uk

Modelling the stromal regulation of tumour angiogenesis, progression and spread Queen Mary, University of London 01/10/2010 30/09/2015 Science Committee - Programme Award Science Committee

Holyoake, Professor Tessa Tessa.Holyoake**[ta]**sgow.ac.uk

Key survival pathways in chronic myeloid leukaemia (CML) stem cells and novel approaches to their eradication University of Glasgow 01/02/2010 31/01/2016 Science Committee - Programme Award Science Committee

Houlston, Professor Richard richard.houlston**[ta]**.ac.uk

CRUK/09/014: MYELOMA XI: A randomised comparison of thalidomide and lenalidomide combinations in myeloma Institute of Cancer Research 01/01/2009 31/12/2017 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

CRUK/09/014: GROMITS+: Genetic Regulation Of Myeloma In Tissue Samples Plus Institute of Cancer Research 01/01/2014 31/12/2015 Clinical Trials Awards & Advisory Committee - Sample Collection Clinical Trials Awards & Advisory Committee

Clinical translational studies of colorectal cancer susceptibility alleles Institute of Cancer Research 01/10/2012 30/09/2015 Science Committee - Programme Award Science Committee

Howe, Professor Franklyn howefa**[ta]**l.ac.uk

MRI biomarkers of low grade glioma growth and infltration.St George's, University of London 01/06/2012 31/05/2017 Science Committee - Biomarker Project Award Science Committee

Howell, Dr Debra debra.howell**[ta]**k.ac.uk

Lymphoma and myeloma: Understanding the patient pathway and promoting early diagnosis University of York 01/07/2012 30/06/2016 National Awareness and Early Diagnosis Initiative - Project Award National Awareness and Early Diagnosis InitiativeCANCER RESEARCH UK our Funded research Principal Investigator email address Project Title host Institution start date end date Funding scheme Funding Commit***

The above is a list of Cancer Research UK’s active publishable awards as of 30 September 2015.For any further enquiries please contact researcher.comments**[ta]**cer.org.uk.Howell, Dr Sacha sacha.howell**[ta]**istie.nhs.uk

CRUK/12/044: FAKTION A phase 1b/randomised placebo controlled phase II trial of fulvestrant +/- AZD5363 in postmenopausal women with advanced breast cancer previously treated with a third generation aromatase inhibitor (AZ/NCRN) Velindre NHS Trust 01/01/2014 31/12/2016 Clinical Trials Awards & Advisory Committee - Feasibility Study Clinical Trials Awards & Advisory Committee

Huang, Dr Danny d.huang**[ta]**tson.gla.ac.uk

Ubiquitin Signalling Cancer Research UK Beatson Institute 01/03/2009 29/02/2016 Biological Sciences Committee - Institute Group Award Science Committee

Huang, Dr Paul paul.huang**[ta]**.ac.uk

A systems approach for characterising functional pathway dependencies in mutant EGFR lung adenocarcinoma Institute of Cancer Research 01/08/2015 31/07/2021 New Investigator Committee - Career Establishment Award New Investigator Committee

Huddart, Dr Robert CRUK/14/016: RAIDER - A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder Institute of Cancer Research 01/12/2014 31/05/2019 Clinical Trials Awards & Advisory Committee - Late Phase Study Clinical Trials Awards & Advisory Committee

Illidge, Professor Tim tmi**[ta]**chester.ac.uk

Developing effective combinations of radiotherapy and immunotherapy in cancer University of Manchester 01/10/2014 30/09/2019 Science Committee - Programme Award Science Committee